Associating cognitive reserve and brain‐wide gene expression regarding Alzheimer's disease

Abstract Background Cognitive reserve (CR) is susceptibility to brain damages, which impacts the development of Alzheimer’s disease (AD). Whereas CR associated with certain subnetworks connectivity, little research has been done on identifying genes that contribute these subnetworks. In this study, we linked regional variation in brain‐wide gene expression. We utilized Allen Human Brain Atlas (AHBA) it comprises expression data spanning whole brain. Method extracted a binary subnetwork regarding from AD patients. Then drew out patterns subnetwork’s regions interest (ROIs) and constructed network through Weighted Gene Co‐expression Network Analysis (WGCNA). To distinctive trait sub‐region (SGN), also whole‐brain (WGN). detected modules (clusters highly interconnected genes) each identified their hub (genes high intra‐modular connectivity). sought non‐preserved, unique SGN compared WGN using median rank statistic. Finally, biological process ontology was investigated by functional enrichment analysis. Result networks based 10544 genes. consisted 90 nodes 49 ROIs. While 18 were SGN, yellow, magenta, red black as modules. Module magenta included novel co‐expressed clusters, other combined classified different WGN. Apoptotic process, including apoptosis‐regulation neuron death, enriched distinctively 4 non‐preserved Neuronal death due apoptosis common pathological feature brains Conclusion co‐expression have specific connectivity related subnetwork. This non‐preservation highlights relevance patterns. Moreover, for risk genes, further demonstrating context AD. study will provide groundwork insights extensive associate connectome‐wide phenotype